First day of renewed hope and immune talk

Before I start, thank you as always for the amazing support as I endured/endure my second miscarriage. I so appreciate it. You guys are awesome.

Today I have finally plucked myself out of the gutter and have started to do some reading. A couple of weeks ago I had an email exchange with my doctor about the way forward, but I have put that information on the backburner whilst I have wallowed in despair and given up on hope. For some reason, today I decided to do something different and started reading and trying to process our current situation with my head, not just my heart. I am going to tell you what my Doctor has said, because I would very much value your opinion. My doctor would like to do the following immune tests:

Antithrombin 3
Factor 5 Leiden
Prothrombin 20210

Are there any other tests you think would be important, from your experiences?

Call it instinct, but when I fell pregnant I actually nearly asked him to do immune testing on me. My father has Psoriasis and my brother rheumatoid athritis and so there has been a nagging voice at the back of my head with a very vague message about immune issues. I wish I had spoken up sooner. Nevertheless, he also recommends (and this is a copy and paste of his email to me):

1. No transfer for a period of at least 6 weeks after the loss we had.

2. To thaw and fertilize the remaining eggs, do PGS on the embryos and transfer only a single euploid (normal) embryo into the uterus

3. Adjuvant therapy will include Intralipid leading up to the transfer of the embryo as well as Clexane 40mg from the day of ET

4. Unfortunately there is no “extra” monitoring to be done other than weekly scans up to about 9 weeks for reassurance.

What do you guys think of this? There is a part of me that feels we may be onto something and that hopefully, we might eventually end up with a positive outcome. Maybe this isn’t the end of the line for me after all.


13 thoughts on “First day of renewed hope and immune talk

  1. Hi hon. Im sorry you’re having such an awful ride. I’m all for immune testing. I never had full immune testing but after our journey, my symptoms, and my family history our last clinic decided to use an autoimmune protocol and for the first time ever (or more to the point the first time I ever made it to test!) we were pregnant. It’s been a rough road but I think knowing there is an issue and being able to treat it is a good thing rather than just trying the same/similar thing again and again with the same results (as our first clinic did). I also think gut instincts are often correct so go with your gut and all the best for getting the answers you need. We’re here for you always. xx


    • The doc has said that he will treat as if there is an immune issue even if I don’t show up with much on the blood tests and that is comforting to me as it resonates with my gut! How are bumble and bee??


      • That’s great! Sounds like you have a good doc.
        Bumble & Bee are doing well…..nearly 28 weeks now and I’m just hoping like crazy they’ll stay put for AT LEAST another 6 weeks.


  2. The tests you list are good to get done…I had them at Cornell. I’d also recommend going to an immunologist. Some REs don’t “believe” in things like NK cells and imflammation markers, others do and test and treat you if your readings are off.


  3. For example, Cornell does not put any stock in the impact of NK cells on implantation/development of a fetus. Sher, on the other hand, does. It makes it frustrating when you just want clear guidance. They’re both great clinics but have wildly different philosophies. My advice is to get all of the testing, do your own research, and go from there. Good luck! 🙂


  4. There are so many immune tests that can be done. I am seeing Dr. Kwak-Kim, a Reproductive Immunologist outside of Chicago. And her practice ran more than 20 immune related tests on me. There are people who will debate the necessity of all that testing, but I always think, the more you know the better. A few that she ran that have had a big impact on my protocol: ANA, APTT, Ant-DNA Histones, Natural Killer Cells Blood Flow Cytometry, TH1/TH2 Cytokine Ration, PAI1 Polymorphism, Prothombin (factor II), F13 A1 Gene. I have a complete list, if you would like it, email me at


  5. I realise that this is an old post. However, I will comment regardless in the hope that it may prove helpful.
    Antiphospholipid syndrome is sort of tricky to prove. You could have elevated antibodies one day and then normal levels again sometime later. It can cause recurrent miscarriages.
    In my case, it was suspected that I had it. Hence I was treated with heparine from the day of testing positive and aspirine cardio 100mg/day from week 14.
    I carried my 4th! pregnancy to term. A few weeks later I was finally diagnosed with antiphospholipid syndrome.
    Best of luck!


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